Life Sciences August 2023

    Articles on epigenetic code, parthenogenesis, waking up the genome…





  • Significant differences appear in the epigenetic code of circulating DNA

    Significant differences appear in the epigenetic code of circulating DNA between healthy subjects and subjects with colorectal cancer. A new high-resolution technique makes it possible to detect cancer early and non-invasively.



    Creating animals capable of reproducing by parthenogenesis

    By genetically manipulating Drosophila flies, researchers have created animals capable of reproducing by parthenogenesis, that is to say without mating or fertilization. The process begins when they are about 40 days old, about halfway through their life.



    Waking up the genome of a newly fertilized egg

    The genome of a newly fertilized egg is inactive and must be woken up to start a new embryo. The information to start the genome activating would be found in a dormant mRNA of the mother which would code for a master transcription factor.



    Brain signals linked to chronic pain and those associated with acute pain

    The brain signals specifically linked to chronic pain are radically different from those associated with acute pain, explaining the ineffectiveness of standard analgesics. The newly discovered signals could act as “objective” biomarkers, which could lead to more precise and effective treatments, such as deep brain stimulation.



    Edit the genome of human cells

    Proteins called Fanzor, enzymes encoded in the eukaryotic genome, use RNA as a guide to target DNA precisely, and can be reprogrammed to edit the genome of human cells. The compact Fanzor systems have the potential to be more easily delivered to cells and tissues as therapeutics than CRISPR/Cas systems.



    A complex network of cell into human body

    Cells in the human body have evolved a complex network of cell cycle checkpoints and DNA damage repair tools, known as the DNA damage response or DDR. The new reference map develops a hierarchical scheme of organizing 605 proteins into 109 assemblies that captures repair mechanisms and proposes novel DDR-associated proteins related to stress, transport and chromatin functions in cells..



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    (78aH*) : August 6th is the anniversary of the atomic bomb explosion on Hiroshima in 1945.
    This date represents the entrance of Humanity into the age of Revelation (Apocalypsis).
    Thus, since August 6, 2023, we are in 78 aH, (meanning 78 after Hiroshima).
    It is also an “atheist” and universal calendar to replace the existing “monotheist”, religious and non universal calendars.